Open AccessExposure to extremely low-frequency magnetic fields and childhood cancer: A systematic review and meta-analysis
Author(s) -
Gyeong Ae Seomun,
Jun-Young Lee,
Jin Kyung Park
Publication year - 2021
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0251628
Subject(s) - odds ratio , medicine , meta analysis , confidence interval , childhood cancer , childhood leukemia , cancer , leukemia , lymphoblastic leukemia
Background Extremely low frequency magnetic fields (ELF-MFs) are classified as a possible carcinogenic factor (Group 2B). This study assessed the association between ELF-MFs and childhood cancer through a systematic review and meta-analysis. Methods Three databases were searched in January 2020. We conducted a meta-analysis for the association between the ELF-MFs exposure level and childhood cancer. Results A total of 33 studies were identified. Thirty studies with 186,223 participants were included in the meta-analysis. Children exposed to 0.2-, 0.3-, and 0.4-μT ELF-MFs had a 1.26 (95% confidence interval [CI] 1.06–1.49), 1.22 (95% CI 0.93–1.61), and 1.72 (95% CI 1.25–2.35) times higher odds of childhood leukemia. In childhood brain tumors, children exposed to 0.2-μT had a 0.95 (95% CI 0.59–1.56) times higher odds, and those exposed to 0.4-μT ELF-MFs had a 1.25 (95% CI 0.93–1.61). Children exposed to 0.2- and 0.4-μT ELF-MFs had a 1.10 (95% CI 0.70–1.75) and 2.01 (95% CI 0.89–4.52) times higher odds of any childhood cancers. Conclusions Significant associations were observed between exposure to ELF-MFs and childhood leukemia. Furthermore, a possible dose-response effect was also observed.