Open AccessSimple fluorescence optosensing probe for spermine based on ciprofloxacin-Tb3+ complexation
Author(s) -
Nguyen Ngoc Nghia,
P.T. Phong,
Jin Sol Han,
Dong-Hee Kwon,
YongIll Lee
Publication year - 2021
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0251306
Subject(s) - detection limit , fluorescence , spermine , chemistry , ciprofloxacin , linker , quenching (fluorescence) , lanthanide , molecule , combinatorial chemistry , selectivity , ion , analytical chemistry (journal) , organic chemistry , chromatography , biochemistry , physics , computer science , operating system , quantum mechanics , enzyme , antibiotics , catalysis
We developed a facile detection method of spermine based on the fluorescence (FL) quenching of the ciprofloxacin-Tb 3+ complex, which shows astrong green emission. Ciprofloxacin (CP) makes efficient bondings to Tb 3+ ion as a linker molecule through carboxylic and ketone groups to form a kind of lanthanide coordination polymer. The addition of spermine that competes with Tb 3+ ions for the interaction with CP due to its positive charge brings about weakened coordination linkage of CP and Tb 3+ . The probe exhibited high sensitivity, selectivity, and good linearity in the range of 2–180 μM with a low limit of detection of 0.17 μM. Moreover, we applied this method on the paper strip test (PST), along with the integration of a smartphone and Arduino-based device. The practical reliability of the developed probe was evaluated on human serum samples with acceptable analytical results.