Open AccessAdvanced glycation end products and cognitive impairment in schizophrenia
Author(s) -
Akiko Kobori,
Mitsuhiro Miyashita,
Yasuhiro Miyano,
Kazuhiro Suzuki,
Kazuya Toriumi,
Kazuhiro Niizato,
Koichiro Oshima,
Atsushi Imai,
Yukihiro Nagase,
Akane Yoshikawa,
Yasue Horiuchi,
Syudo Yamasaki,
Atsushi Nishida,
Satoshi Usami,
Shunya Takizawa,
Masanari Itokawa,
Heii Arai,
Makoto Arai
Publication year - 2021
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0251283
Subject(s) - glycation , pentosidine , advanced glycation end product , schizophrenia (object oriented programming) , wechsler adult intelligence scale , cognition , effects of sleep deprivation on cognitive performance , wisconsin card sorting test , medicine , cognitive decline , neuropsychology , psychology , psychiatry , dementia , disease , receptor
Advanced glycation end products play a key role in the pathophysiology of schizophrenia. Cognitive impairment is one of the central features of schizophrenia; however, the association between advanced glycation end products and cognitive impairment remains unknown. This study investigated whether advanced glycation end products affect the cognitive domain in patients with schizophrenia. A total of 58 patients with chronic schizophrenia were included in this cross-sectional study. Plasma advanced glycation end products were measured using high-performance liquid chromatography (HPLC). Neuropsychological and cognitive functions were assessed using the Wechsler Adult Intelligence Scale, Third Version, and the Wisconsin Card Sorting Test Keio-FS version. Multiple regression analysis adjusted for age, sex, body mass index, educational years, daily dose of antipsychotics, and psychotic symptoms revealed that processing speed was significantly associated with plasma pentosidine, a representative advanced glycation end product (standardized β = -0.425; p = 0.009). Processing speed is the cognitive domain affected by advanced glycation end products. Considering preceding evidence that impaired processing speed is related to poor functional outcome, interventions targeted at reducing advanced glycation end products may contribute to promoting recovery of patients with schizophrenia as well as cognitive function improvement.