Open AccessSynergistic effects of Cu-doped ZnO nanoantibiotic against Gram-positive bacterial strains
Author(s) -
Awais Khalid,
Pervaiz Ahmad,
Abdulrahman I. Alharthi,
Saleh Muhammad,
Mayeen Uddin Khandaker,
Mohammad Rashed Iqbal Faruque,
Israf Ud Din,
Mshari A. Alotaibi,
Abdulhameed Khan
Publication year - 2021
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0251082
Subject(s) - wurtzite crystal structure , zinc , nuclear chemistry , x ray photoelectron spectroscopy , scanning electron microscope , zinc hydroxide , materials science , chemistry , chemical engineering , organic chemistry , engineering , composite material
A viable hydrothermal technique has been explored for the synthesis of copper doped Zinc oxide nanoparticles (Cu-doped ZnO-NPs) based on the precursor’s mixture of Copper-II chloride dihydrate (CuCl 2 .2H 2 O), Zinc chloride (ZnCl 2 ), and potassium hydroxide (KOH). X-ray diffraction (XRD) reported the hexagonal wurtzite structure of the synthesized Cu-doped ZnO-NPs. The surface morphology is checked via field emission scanning electron microscopy (FE-SEM), whereas, the elemental compositions of the samples were confirmed by Raman, and X-ray photoelectron spectroscopy (XPS), respectively. The as-obtained ZnO-NPs and Cu-doped ZnO-NPs were then tested for their antibacterial activity against clinical isolates of Gram-positive ( Staphylococcus aureus , Streptococcus pyogenes ) and Gram-negative ( Escherichia coli , Klebsiella pneumonia ) bacteria via agar well diffusion method. The zone of inhibition (ZOI) for Cu-doped ZnO-NPs was found to be 24 and 19 mm against S. Aureus and S. pyogenes, and 18 and 11 mm against E. coli and K. pneumoniae, respectively. The synthesized Cu-doped ZnO-NPs can thus be found as a potential nano antibiotic against Gram-positive multi-drug resistant bacterial strains.