Open AccessThe factors affecting the physical development of neonates in pregnant women with or without gestational diabetes mellitus
Author(s) -
Xiaolei Zhao,
Nana Li,
Ru Jia,
Shumin Chen,
Ling Wang
Publication year - 2021
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0251024
Subject(s) - medicine , gestational diabetes , underweight , obstetrics , birth weight , pregnancy , gestational age , fetal macrosomia , diabetes mellitus , risk factor , body mass index , gynecology , gestation , overweight , endocrinology , genetics , biology
Objectives To explore the factors affecting neonatal physical development in pregnant women with or without gestational diabetes mellitus (GDM). Methods The subjects were selected from the pregnant woman giving birth in 2 nd Affiliated Hospital of Zhengzhou University, from November 2015 to May 2016. The age, occupation, education level, gestational age, body weight before pregnancy, body weight at delivery, body height, delivery pattern, GDM status of pregnant women and neonatal gender, birth weight (BW), chest circumference (CC), head circumference (HC) and birth length (BL) were collected through medical records and questionnaires. The clinical data were retrospectively analyzed and studied. Results The significant differences were found between women with GDM and without GDM in following neonatal variables ( P <0.05): BW, CC, and HC. GDM status increased the incidence of macrosomia ( OR = 2.241, 95% CI : 1.406–3.573), large CC ( OR = 2.470, 95% CI : 1.687–3.6153). Gestational weight gain (GWG) above IOM guideline was risk factor for macrosomia ( OR = 1.763, 95% CI :1.098–2.833), large HC (OR = 1,584, 95% CI : 1.093–2.296) and large CC ( OR = 1.707, 95% CI :1.163–2.506). Underweight was risk factor for short BL ( OR = 2.543, 95% CI :1.161–5.571) and small CC ( OR = 1.901, 95% CI :1.064–3.394). Female neonate was prone to appear short BL( OR = 2.831, 95% CI : 1.478–5.422) and small HC ( OR = 2.750, 95% CI : 1.413–5.350), and not likely to macrosomia ( OR = 0.538, 95% CI : 0.343–0.843), longer BL ( OR = 0.584, 95% CI : 0.401–0.850), large HC ( OR = 0.501, 95% CI : 0.352–0.713), and ( OR = 0.640, 95% CI : 0.446–0.917). For women with GDM, gestational age was an risk factor of neonatal BW (low BW: OR = 0.207, 95% CI : 0.085–0.503; macrosomia: OR = 1.637, 95% CI : 1.177–2.276), BL (short BL: OR = 0.376, 95% CI : 0.241–0.585; long BL: OR = 1.422, 95% CI : 1.054–1.919), HC (small HC: OR = 0.343, 95% CI : 0.202–0.583; large HC: OR = 1.399, 95% CI : 1.063–1.842) and CC (small CC: OR = 0.524, 95% CI : 0.374–0.733; large CC: OR = 1.485, 95% CI : 1.138–1.936). Conclusions In our study, gestational age, GDM status, neonatal gender, GWG and pre-pregnancy body mass index (BMI) are associated the abnormal physical development of neonates. In women with GDM, gestational age was correlate with neonatal abnormal physical developments.