Open AccessRelationship between childhood physical abuse and clinical severity of treatment-resistant depression in a geriatric population
Author(s) -
Antoine Yrondi,
Christophe Arbus,
Djamila Bennabi,
Thierry d’Amato,
Frank Bellivier,
Thierry Bougerol,
Vincent Camus,
Philippe Courtet,
Olivier Doumy,
Jean-Baptiste Genty,
Jérôme Holtzmann,
M. Hörn,
Christophe Lançon,
Marion Leboyer,
PierreMichel Llorca,
Julia Maruani,
Rémi Moirand,
Fanny Molière,
J. Petrucci,
Raphaëlle Richieri,
Ludovic Samalin,
Florian Stéphan,
Guillaume Vaïva,
Michel Walter,
Emmanuel Haffen,
Bruno Aouizerate,
Wissam ElHage
Publication year - 2021
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0250148
Subject(s) - depression (economics) , medicine , rating scale , cohort , correlation , psychiatry , psychology , developmental psychology , economics , macroeconomics , geometry , mathematics
We assessed the correlation between childhood maltreatment (CM) and severity of depression in an elderly unipolar Treatment-Resistant Depression (TRD) sample. Methods Patients were enrolled from a longitudinal cohort (FACE-DR) of the French Network of Expert TRD Centres. Results Our sample included 96 patients (33% of the overall cohort) aged 60 years or above, with a mean age of 67.2 (SD = 5.7). The majority of the patients were female (62.5%). The Montgomery and Asberg Depression Rating Scale (MADRS) and Quick Inventory Depression Scale-Self Report (QIDS-SR) mean scores were high, 28.2 (SD = 7.49) [MADRS score range: 0–60; moderate severity≥20, high severity≥35] and 16.5 (SD = 4.94) [IDS-SR score range: 0–27; moderate severity≥11, high severity≥16], respectively. Mean self-esteem scores were 22.47 (SD = 6.26) [range 0–30]. In an age- and sex-adjusted model, we found a positive correlation between childhood trauma (CTQ scores) and depressive symptom severity [MADRS (β = 0.274; p = 0.07) and QIDS-SR (β = 0.302; p = 0.005) scores]. We detected a statistically significant correlation between physical abuse and depressive symptom severity [MADRS (β = 0.304; p = 0.03) and QIDS-SR (β = 0.362; p = 0.005) scores]. We did not observe any significant correlation between other types of trauma and depressive symptom severity. We showed that self-esteem (Rosenberg scale) mediated the effect of physical abuse (PA) on the intensity of depressive symptoms [MADRS: b = 0.318, 95% BCa C . I . [0.07, 0.62]; QIDS-SR: b = 0.177, 95% BCa C . I . [0.04, 0.37]]. Preacher & Kelly’s Kappa Squared values of 19.1% ( k 2 = 0.191) and 16% ( k 2 = 0.16), respectively for the two scales, indicate a moderate effect. Conclusion To our knowledge, this is the first study conducted in a geriatric TRD population documenting an association between childhood trauma (mainly relating to PA) and the intensity of depressive symptoms.