Open AccessThe bone bridge significantly affects the decrease in bone mineral density measured with quantitative computed tomography in ankylosing spondylitis
Author(s) -
So Yun Lee,
Ran Song,
Haesik Yang,
Sang Wan Chung,
Yeon-Ah Lee,
SeungJae Hong,
Seong Jong Yun,
Sanghoon Lee
Publication year - 2021
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0249578
Subject(s) - medicine , quantitative computed tomography , bone mineral , osteopenia , osteoporosis , ankylosing spondylitis , bone density , reduction (mathematics) , bridge (graph theory) , trabecular bone score , lumbar vertebrae , nuclear medicine , lumbar , radiology , surgery , geometry , mathematics
and objective Ankylosing spondylitis (AS) has characteristics of spinal bone bridge and fusion. Although BMD reduction in AS may be presumed to be due to spinal inflammation, this study was designed to confirm whether immobilization of the spine due to syndesmophytes is related to BMD reduction, as immobilization itself is a risk factor for BMD reduction. Methods Among male patients diagnosed with AS according to the modified New York criteria, those who underwent bone density tests with quantitative computed tomography (QCT) were retrospectively analyzed through a chart review. The correlation between the presence or absence of bone bridges for each vertebral body level of the L spine confirmed with radiography and BMD confirmed with QCT was analyzed. Results A total of 47 male patients with AS were enrolled. The mean patient age was 46.8 ± 8.2 years, and the mean disease duration was 7.9 ± 6.4 years. The trabecular BMD of the lumbar spine (L1-L4) ranged from 23.1 to 158.45 mg/cm 3 (mean 102.2 ± 37 mg/cm 3 ), as measured with QCT. The lumbar BMD measurements showed that 30 patients (63.8%) had osteopenia or osteoporosis. Bone bridge formation showed a negative correlation with BMD. Low BMD was significantly correlated with bone bridge in the vertebral body ( p < 0.05). Positive correlations were observed between bone bridge score and BASMI flexion score, whereas significant negative correlations were found between BMD and BASMI flexion score ( p < 0.05). Conclusion Decreased mobility of the vertebrae due to bone bridge formation affects the decrease in BMD in patients with AS.