Open AccessSilicon-containing water intake confers antioxidant effect, gastrointestinal protection, and gut microbiota modulation in the rodents
Author(s) -
Wei Wu,
Pei Li Chou,
JyhChin Yang,
Chiang Ting Chien
Publication year - 2021
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0248508
Subject(s) - gut flora , food science , antioxidant , lactobacillus reuteri , microbiology and biotechnology , chemistry , gastrointestinal tract , lactobacillus , gastrointestinal function , reactive oxygen species , biology , biochemistry , medicine , fermentation
We explored the effects of silicon-containing water (BT) intake on gastrointestinal function and gut microbiota. BT was obtained by pressuring tap water through silicon minerals (mullite, Al 6 Si 2 O 13 ) column. BT decreased H 2 O 2 chemiluminescence counts, indicating its antioxidant activity. Four weeks of BT drinking increased H 2 O 2 scavenging activity and glutathione peroxidase activity of plasma. BT drinking did not affect the body weight but significantly reduced the weight of feces and gastrointestinal motility. BT drinking significantly suppressed pylorus ligation enhanced gastric juice secretion, gastric reactive oxygen species amount, erythrocyte extravasation, IL-1β production by infiltrating leukocyte, and lipid peroxidation within gastric mucosa. Data from 16S rRNA sequencing revealed BT drinking significantly increased beneficial flora including Ruminococcaceae UCG-005, Prevotellaceae NK3B31, Weissella paramesenteroides , Lactobacillus reuteri , and Lactobacillus murinus and decreased harmful flora including Mucispirillum , Rodentibacter , and Staphylococcus aureus . This study pioneerly provided scientific evidences for the potential effects of water-soluble forms of silicon intake on antioxidant activity, gastrointestinal function, and gut microbiota modulation.