A convenient approach to synthesize substituted 5-Arylidene-3-m-tolyl thiazolidine-2, 4-diones by using morpholine as a catalyst and its theoretical study | Zendy

Khorshada Jahan | Zendy; Kaif Rashid Khan | Zendy; Kawsari Akhter | Zendy; Umme Kulsum Rowzatur Romman | Zendy; Ershad Halim | Zendy

Open Access

A convenient approach to synthesize substituted 5-Arylidene-3-m-tolyl thiazolidine-2, 4-diones by using morpholine as a catalyst and its theoretical study

Author(s) -

Khorshada Jahan,

Kaif Rashid Khan,

Kawsari Akhter,

Umme Kulsum Rowzatur Romman,

Ershad Halim

Publication year - 2021

Publication title -

plos one

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.99

H-Index - 332

ISSN - 1932-6203

DOI - 10.1371/journal.pone.0247619

Subject(s) - morpholine , thiazolidinedione , docking (animal) , chemistry , thiazolidine , catalysis , peroxisome proliferator activated receptor , stereochemistry , combinatorial chemistry , receptor , medicinal chemistry , biochemistry , type 2 diabetes , diabetes mellitus , biology , medicine , nursing , endocrinology

Thiazolidinediones are very important and used as a drug for the treatment of type 2 diabetes. Here, we report a convenient approach to synthesis 3-m-tolyl-5-arylidene-2,4-thiazolidinediones (TZDs) derivatives 7a-e in two steps with moderate to good yield using morpholine as a catalyst. All the structures were confirmed by their spectral IR, 1 H NMR and 13 C NMR data. The anti-diabatic activity of all synthesized molecules is evaluated by docking with peroxisome proliferator-activated receptor-γ (PPARγ). Preliminary flexible docking studies reveals that our compounds 7a , 7d and 7e showed better binding affinity with the protein and could be a potential candidate for the treatment of type 2 diabetes in near future.

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