Open AccessNMR spectroscopy reveals acetylsalicylic acid metabolites in the human urine for drug compliance monitoring
Author(s) -
G. S. Kupriyanova,
Vladimir Rafalskiy,
Ivan Mershiev,
Ekaterina Moiseeva
Publication year - 2021
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0247102
Subject(s) - urine , compliance (psychology) , drug , aspirin , medicine , pharmacology , nuclear magnetic resonance spectroscopy , intensive care medicine , chemistry , psychology , social psychology , organic chemistry
Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Long-term use of antiplatelet drugs is a well-studied therapy for the prevention of cardiovascular death. Ensuring compliance with lifelong administration of antiplatelet drugs, in particular acetylsalicylic acid, is one of the challenges of such therapy. The aim of this study is to explore the possibility of using nuclear magnetic resonance spectroscopy to identify acetylsalicylic acid metabolites in urine and to search for characteristic markers that could be used to detect patient compliance with long-term acetylsalicylic acid treatment.