Open AccessComparative study between photodynamic therapy with urucum + Led and probiotics in halitosis reduction–protocol for a controlled clinical trial
Author(s) -
Pamella de Barros Motta,
Lara Jansiski Motta,
Ana Carolina Costa da Mota,
Marcela Letícia Leal Gonçalves,
Tamiris Silva,
Marcos Momolli,
David Andrade,
Kristianne Porta Santos Fernandes,
Raquel Agnelli MesquitaFerrari,
Alessandro Melo Deana,
Mark Wainwright,
Renato Araújo Prates,
Anna Carolina Ratto Tempestini Horliana,
Sandra Kalil Bussadori
Publication year - 2021
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0247096
Subject(s) - medicine , dentistry , dental floss , tooth brushing , tongue , analysis of variance , toothbrush , brush , pathology , electrical engineering , engineering
Background Halitosis is a term that defines any foul odor emanating from the oral cavity. The origin may be local or systemic. The aim of the proposed protocol is to determine whether treatment with antimicrobial photodynamic therapy (aPDT) and treatment with probiotics are effective at eliminating halitosis. Materials and methods Eighty-eight patients, from 18 to 25 years old with a diagnosis of halitosis (H 2 S≥112 ppb, determined by gas chromatography) will be randomly allocated to four groups (n = 22) that will receive different treatments: Group 1 –treatment with teeth brushing, dental floss and tongue scraper; Group 2 –brushing, dental floss and aPDT; Group 3 –brushing, dental floss and probiotics; Group 4 –brushing, flossing, aPDT and probiotics. The results of the halimetry will be compared before, immediately after, seven days and thirty days after treatment. The microbiological analysis of the coated tongue will be performed at these same times. The normality of the data will be determined using the Shapiro-Wilk test. Data with normal distribution will be analyzed using analysis of variance (ANOVA). Non-parametric data will be analyzed using the Kruskal-Wallis test. The Wilcoxon test will be used to analyze the results of each treatment at the different evaluation periods. Clinical trail registration NCT03996044 .