Open AccessNationwide incidence of sarcomas and connective tissue tumors of intermediate malignancy over four years using an expert pathology review network
Author(s) -
Gonzague de Pinieux,
Marie Karanian,
François Le Loarer,
Sophie Le Guellec,
Sylvie Chabaud,
Philippe Terrier,
Corinne Bouvier,
Maxime Batistella,
Agnès Neuville,
YvesMarie Robin,
Jean–François Emile,
Anne Moreau,
Frédérique Larousserie,
Agnès Leroux,
Nathalie Stock,
Marick Laé,
Françoise Collin,
Nicolas Weinbreck,
Sébastien Aubert,
Florence Mishellany,
Céline CharonBarra,
Sabrina Croce,
Laurent Doucet,
Isabelle Quintin-Rouet,
Marie-Christine Château,
Céline Bazille,
Isabelle Valo,
Bruno Chetaille,
Nicolas Ortonne,
A. Brouchet,
Philippe Rochaix,
Anne Demuret,
Jean-Pierre Ghnassia,
Lénaïg Mescam,
Nicolas Macagno,
Isabelle Birtwisle-Peyrottes,
Christophe Delfour,
Émilie Angot,
Isabelle Pommepuy,
Dominique Ranchère,
Claire Chemin-Airiau,
Myriam JeanDenis,
Yohan Fayet,
Jean-Baptiste Courrèges,
Nouria Mesli,
Juliane Berchoud,
Maud Toulmonde,
Antoîne Italiano,
Axel Le Cesne,
Nicolas Penel,
Françoise Ducimetière,
F. Gouin,
JeanMichel Coindre,
JeanYves Blay,
NetSarc,
Repps,
ResSos
Publication year - 2021
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0246958
Subject(s) - incidence (geometry) , sarcoma , medicine , malignancy , gist , leiomyosarcoma , liposarcoma , pathology , stromal cell , physics , optics
Background Since 2010, nationwide networks of reference centers for sarcomas (RREPS/NETSARC/RESOS) collected and prospectively reviewed all cases of sarcomas and connective tumors of intermediate malignancy (TIM) in France. Methods The nationwide incidence of sarcoma or TIM (2013–2016) was measured using the 2013 WHO classification and confirmed by a second independent review by expert pathologists. Simple clinical characteristics, yearly variations and correlation of incidence with published clinical trials are presented and analyzed. Results Over 150 different histological subtypes are reported from the 25172 patients with sarcomas (n = 18712, 74,3%) or TIM (n = 6460, 25.7%), with n = 5838, n = 6153, n = 6654, and n = 6527 yearly cases from 2013 to 2016. Over these 4 years, the yearly incidence of sarcomas and TIM was therefore 70.7 and 24.4 respectively, with a combined incidence of 95.1/10 6 /year, higher than previously reported. GIST, liposarcoma, leiomyosarcomas, undifferentiated sarcomas represented 13%, 13%, 11% and 11% of tumors. Only GIST, as a single entity had a yearly incidence above 10/10 6 /year. There were respectively 30, 64 and 66 different histological subtypes of sarcomas or TIM with an incidence ranging from 10 to 1/10 6 , 1–0.1/10 6 , or < 0.1/10 6 /year respectively. The 2 latter incidence groups represented 21% of the patients with 130 histotypes. Published phase III and phase II clinical trials (p<10 −6 ) are significantly higher with sarcomas subtypes with an incidence above 1/10 6 per. Conclusions This nationwide registry of sarcoma patients, with exhaustive histology review by sarcoma experts, shows that the incidence of sarcoma and TIM is higher than reported, and that tumors with a very low incidence (1<10 6 /year) are less likely to be included in clinical trials.