Open AccessPrevalence of Escherichia coli O157:H7 and associated factors in under-five children in Eastern Ethiopia
Author(s) -
Dawit Kassaye Getaneh,
Lemessa Oljira Hordofa,
Desalegn Admassu Ayana,
Tesfaye Sisay Tessema,
Lemma Demissie Regassa
Publication year - 2021
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0246024
Subject(s) - diarrhea , odds ratio , bloody diarrhea , medicine , confidence interval , logistic regression , escherichia coli , veterinary medicine , traveler's diarrhea , biology , biochemistry , gene
Background Escherichia coli O157:H7 ( E . coli O157:H7) is one of the most potent zoonotic pathogens that causes mild diarrhea and leads to hemolytic uremic syndrome or death. This study was aimed to assess the prevalence and determinants of E . coli O157:H7 related to diarrhea among under-five children with acute diarrhea. Methods A cross-sectional study design was carried out in 2018 on 378 under-five-year children recruited randomly from hospitals in Eastern Ethiopia. Stool specimens were collected and processed using enrichment, differential and selective medium. Among isolates, E . coli O157:H7 was confirmed using latex test (Oxoid, Basingstoke, Hants, England). Factors associated with E . coli O157:H7 infection were identified using binary and multivariable logistic regression. Associations were reported by odds ratio with 95% confidence interval. Results The prevalence of E . coli O157:H7 related diarrhea was 15.3% (95%CI: 11.8–19.5). The E . coli O157:H7 infection was positively associated with rural residence (AOR;3.75, 95%CI:1.26–11.20), consumption of undercooked meat (AOR;3.95, 95%CI: 1.23–12.67), raw vegetables and/or fruit juice (AOR;3.37, 95%CI:1.32–8.62), presence of bloody diarrhea (AOR;4.42, 95% CI:1.78–10.94), number of under-five children in a household (AOR;7.16, 95%CI: 2.90–17.70), presence of person with diarrhea in a household (AOR;4.22, 95% CI: 1.84–12.69), owning domestic animal (AOR;3.87, 95% CI: 1.48–10.12) and uneducated mother (AOR;3.14, 95%CI: 1.05–9.42). Conclusion The Prevalence of E . coli O157:H7 related diarrhea among under-five children is relatively high in Eastern Ethiopia. The E. coli infection was associated with sanitation and hygiene in a household. Thus, education focused on food cooking and handling, child care, and household sanitation associated with animal manure in rural resident children are helpful in.