Open AccessThe effect of breast density on the missed lesion rate in screening digital mammography determined using an adjustable-density breast phantom tailored to Japanese women
Author(s) -
Mika Yamamuro,
Yoshiyuki Asai,
Naomi Hashimoto,
Naohiro Yasuda,
Yoshiharu Ozaki,
Kazunari Ishii,
Yongbum Lee
Publication year - 2021
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0245060
Subject(s) - mammography , medicine , imaging phantom , microcalcification , digital mammography , breast density , radiology , lesion , nuclear medicine , breast imaging , receiver operating characteristic , breast cancer , pathology , cancer
Objective Despite the high risk of missing lesions in mammography, the missed lesion rate is yet to be clinically established. Further, no breast phantoms with adjustable breast density currently exist. We developed a novel, adjustable-density breast phantom with a composition identical to that of actual breasts, and determined the quantitative relationship between breast density and the missed lesion rate in mammography. Methods An original breast phantom consisting of adipose- and fibroglandular-equivalent materials was developed, and a receiver operating characteristic (ROC) study was performed. Breast density, which is the fraction by weight of fibroglandular to total tissue, was adjusted to 25%, 50%, and 75% by arbitrarily mixing the two materials. Microcalcification, mass lesions, and spiculated lesions, each with unique characteristics, were inserted into the phantom. For the above-mentioned fibroglandular densities, 50 positive and 50 negative images for each lesion type were used as case samples for the ROC study. Five certified radiological technologists participated in lesion detection. Results The mass-lesion detection rate, according to the area under the curve, decreased by 18.0% ( p = 0.0001, 95% Confidence intervals [CI] = 0.1258 to 0.1822) and 37.8% ( p = 0.0003, 95% CI = 0.2453 to 0.4031) for breast densities of 50% and 75%, respectively, compared to that for a 25% breast density. A similar tendency was observed with microcalcification; however, spiculated lesions did not follow this tendency. Conclusions We quantified the missed lesion rate in different densities of breast tissue using a novel breast phantom, which is imperative for advancing individualized screening mammography.