Open AccessDALIA- a comprehensive resource of Disease Alleles in Arab population
Author(s) -
Aastha Vatsyayan,
Parul Sharma,
Shrey Gupta,
Sumiti Sandhu,
Seetha Lakshmi Venu,
Vandana Sharma,
Bouabid Badaoui,
Kaidi Azedine,
Serti Youssef,
Anna Rajab,
Alaaeldin Fayez,
Seema Madinur,
Anop Singh Ranawat,
Kavita Pandhare,
Srinivasan Ramachandran,
Sridhar Sivasubbu,
Vinod Scaria
Publication year - 2021
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0244567
Subject(s) - compendium , population , genetic epidemiology , genetic diversity , disease , biology , genetics , medicine , environmental health , geography , pathology , archaeology
The Arab population encompasses over 420 million people characterized by genetic admixture and a consequent rich genetic diversity. A number of genetic diseases have been reported for the first time from the population. Additionally a high prevalence of some genetic diseases including autosomal recessive disorders such as hemoglobinopathies and familial mediterranean fever have been found in the population and across the region. There is a paucity of databases cataloguing genetic variants of clinical relevance from the population. The availability of such a catalog could have implications in precise diagnosis, genetic epidemiology and prevention of disease. To fill in the gap, we have compiled DALIA, a comprehensive compendium of genetic variants reported in literature and implicated in genetic diseases reported from the Arab population. The database aims to act as an effective resource for population-scale and sub-population specific variant analyses, enabling a ready reference aiding clinical interpretation of genetic variants, genetic epidemiology, as well as facilitating rapid screening and a quick reference for evaluating evidence on genetic diseases.