Open AccessAssociation between prostate cancer characteristics and BRCA1/2-associated family cancer history in a Japanese cohort
Author(s) -
Yudai Ishiyama,
Masaki Shimbo,
Junpei Iizuka,
Gautam A. Deshpande,
Kazunari Tanabe,
Kazunori Hattori
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0244149
Subject(s) - medicine , family history , prostate cancer , cancer , oncology , ovarian cancer , pancreatic cancer , breast cancer , prostate , prostate specific antigen , stage (stratigraphy) , gynecology , cohort , biology , paleontology
In addition to breast, ovarian, and pancreatic cancers, BRCA1/2 genes have been associated with prostate cancer (PC). However, the role of BRCA1/2 -associated family cancer history (FCH) has remained unexplored in treating these four cancer types as a homogenous pathophysiological group. We aimed to clarify the relationship between BRCA1/2 -associated FCH and PC, and to assess its relationship with cancer aggressiveness. Patient characteristics, positive family history of BRCA1/2 -associated cancer, and cancer characteristics (Gleason score, prostate specific antigen level at diagnosis, and clinical tumor stage) were analyzed. Among the 1,985 eligible candidates, 473 (23.83%) patients had adequately detailed FCH, obtained via questionnaire, and were thus included in the study. BRCA1/2 -associated FCH was observed in 135 (28.54%) patients with PC (68, 14.38%), breast (44, 9.30%), pancreatic (31, 6.55%), or ovarian (8, 1.69%) cancers. BRCA1/2 -associated FCH was not significantly associated with high Gleason score (≥ 8). Patients with BRCA -associated FCH were less likely to present with high clinical tumor stage, and no difference was observed in prostate-specific antigen level, presence of metastatic lesions at diagnosis, or likelihood of high-risk classification between patients with and without BRCA -associated FCH. This is the first report of BRCA1/2 -associated FCH in Japanese men, indicating that family history did not affect the severity or aggressiveness of PC.