Open AccessMathematical modelling and control of African animal trypanosomosis with interacting populations in West Africa—Could biting flies be important in main taining the disease endemicity?
Author(s) -
Paul Olalekan Odeniran,
Akindele Akano Onifade,
Ewan T. MacLeod,
Isaiah Oluwafemi Ademola,
Simon Alderton,
Susan C. Welburn
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0242435
Subject(s) - biology , biting , wildlife , vector (molecular biology) , trypanosoma vivax , population , tsetse fly , livestock , basic reproduction number , veterinary medicine , ecology , trypanosoma , zoology , virology , environmental health , genetics , medicine , gene , recombinant dna
African animal trypanosomosis (AAT) is transmitted cyclically by tsetse flies and mechanically by biting flies (tabanids and stomoxyines) in West Africa. AAT caused by Trypanosoma congolense , T. vivax and T. brucei brucei is a major threat to the cattle industry. A mathematical model involving three vertebrate hosts (cattle, small ruminants and wildlife) and three vector flies (Tsetse flies, tabanids and stomoxyines) was described to identify elimination strategies. The basic reproduction number ( R 0 ) was obtained with respect to the growth rate of infected wildlife (reservoir hosts) present around the susceptible population using a next generation matrix technique. With the aid of suitable Lyapunov functions, stability analyses of disease-free and endemic equilibria were established. Simulation of the predictive model was presented by solving the system of ordinary differential equations to explore the behaviour of the model. An operational area in southwest Nigeria was simulated using generated pertinent data. The R 0 < 1 in the formulated model indicates the elimination of AAT. The comprehensive use of insecticide treated targets and insecticide treated cattle (ITT/ITC) affected the feeding tsetse and other biting flies resulting in R 0 < 1. The insecticide type, application timing and method, expertise and environmental conditions could affect the model stability. In areas with abundant biting flies and no tsetse flies, T. vivax showed R 0 > 1 when infected wildlife hosts were present. High tsetse populations revealed R 0 <1 for T. vivax when ITT and ITC were administered, either individually or together. Elimination of the transmitting vectors of AAT could cost a total of US$ 1,056,990 in southwest Nigeria. Hence, AAT in West Africa can only be controlled by strategically applying insecticides targeting all transmitting vectors, appropriate use of trypanocides, and institutionalising an appropriate barrier between the domestic and sylvatic areas.