Open AccessPerformance of serum apolipoprotein-A1 as a sentinel of Covid-19
Author(s) -
Thierry Poynard,
Olivier Deckmyn,
Marika Rudler,
Valentina Peta,
Yen Ngo,
Mathieu Vautier,
Sepideh Akhavan,
Vincent Cálvez,
Clemence Franc,
Jean Marie Castille,
Fabienne Drane,
Mehdi Sakka,
Dominique BonnefontRousselot,
Jean Marc Lacorte,
David Saadoun,
Yves Allenbach,
Olivier Benveniste,
Frédérique Gandjbakhch,
Julien Mayaux,
Olivier Lucidarme,
Bruno Fautrel,
Vlad Ratziu,
Chantal Housset,
Dominique Thabut,
Patrice Cacoub
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0242306
Subject(s) - apolipoprotein b , medicine , apolipoprotein a1 , population , covid-19 , gastroenterology , pneumonia , cholesterol , disease , infectious disease (medical specialty) , environmental health
Background Since 1920, a decrease in serum cholesterol has been identified as a marker of severe pneumonia. We have assessed the performance of serum apolipoprotein-A1, the main transporter of HDL-cholesterol, to identify the early spread of coronavirus disease 2019 (Covid-19) in the general population and its diagnostic performance for the Covid-19. Methods We compared the daily mean serum apolipoprotein-A1 during the first 34 weeks of 2020 in a population that is routinely followed for a risk of liver fibrosis risk in the USA (212,297 serum) and in France (20,652 serum) in relation to a local increase in confirmed cases, and in comparison to the same period in 2019 (266,976 and 28,452 serum, respectively). We prospectively assessed the sensitivity of this marker in an observational study of 136 consecutive hospitalized cases and retrospectively evaluated its specificity in 7,481 controls representing the general population. Results The mean serum apolipoprotein-A1 levels in the survey populations began decreasing in January 2020, compared to the same period in 2019. This decrease was highly correlated with the daily increase in confirmed Covid-19 cases in the following 34 weeks, both in France and USA, including the June and mid-July recovery periods in France. Apolipoprotein-A1 at the 1.25 g/L cutoff had a sensitivity of 90.6% (95%CI84.2–95.1) and a specificity of 96.1% (95.7–96.6%) for the diagnosis of Covid-19. The area under the characteristics curve was 0.978 (0.957–0.988), and outperformed haptoglobin and liver function tests. The adjusted risk ratio of apolipoprotein-A1 for survival without transfer to intensive care unit was 5.61 (95%CI 1.02–31.0; P = 0.04). Conclusion Apolipoprotein-A1 could be a sentinel of the pandemic in existing routine surveillance of the general population. NCT01927133, CER-2020-14.