Open AccessVariant analysis of 1,040 SARS-CoV-2 genomes
Author(s) -
Eric C. Rouchka,
Julia H. Chariker,
Donghoon Chung
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0241535
Subject(s) - genome , genbank , biology , genetics , intergenic region , coronavirus , coding region , population , human genome , untranslated region , computational biology , gene , virology , rna , covid-19 , medicine , infectious disease (medical specialty) , disease , environmental health , pathology
The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) viral genome is an RNA virus consisting of approximately 30,000 bases. As part of testing efforts, whole genome sequencing of human isolates has resulted in over 1,600 complete genomes publicly available from GenBank. We have performed a comparative analysis of the sequences, in order to detect common mutations within the population. Analysis of variants occurring within the assembled genomes yields 417 variants occurring in at least 1% of the completed genomes, including 229 within the 5’ untranslated region (UTR), 152 within the 3’UTR, 2 within intergenic regions and 34 within coding sequences.