Open AccessCommon childhood vaccines do not elicit a cross-reactive antibody response against SARS-CoV-2
Author(s) -
Ahmed Kandeil,
Mokhtar R. Gomaa,
Ahmed El Taweel,
Ahmed Mostafa,
Mahmoud Shehata,
Ahmed S. Kayed,
Omnia Kutkat,
Yassmin Moatasim,
Sara H. Mahmoud,
Mibil Kamel,
Noura M. Abo Shama,
Mohamed El Sayes,
Rabeh ElShesheny,
Mahmoud A. Yassien,
Richard J. Webby,
Ghazi Kayali,
Mohamed A. Ali
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0241471
Subject(s) - vaccination , medicine , measles , rubella , immunology , diphtheria , virology , antibody , immunity , tetanus , hepatitis a , neutralizing antibody , immune system , hepatitis
Anecdotal evidence showed a negative correlation between Bacille Calmette-Guérin (BCG) vaccination and incidence of COVID-19. Incidence of the disease in children is much lower than in adults. It is hypothesized that BCG and other childhood vaccinations may provide some protection against SARS-CoV-2 infection through trained or adaptive immune responses. Here, we tested whether BCG, Pneumococcal, Rotavirus, Diphtheria, Tetanus, Pertussis, Hepatitis B, Haemophilus influenzae, Hepatitis B, Meningococcal, Measles, Mumps, and Rubella vaccines provide cross-reactive neutralizing antibodies against SARS-CoV-2 in BALB/c mice. Results indicated that none of these vaccines provided antibodies capable of neutralizing SARS-CoV-2 up to seven weeks post vaccination. We conclude that if such vaccines have any role in COVID-19 immunity, this role is not antibody-mediated.