Open AccessEvaluation of viral co-infections among patients with community-associated Clostridioides difficile infection
Author(s) -
Lauren Korhonen,
Jessica Cohen,
Nicole Gregoricus,
Monica M. Farley,
Rebecca Perlmutter,
Stacy Holzbauer,
Ghinwa Dumyati,
Zintars G. Beldavs,
Ashley Paulick,
Jan Vinjé,
Brandi Limbago,
Fernanda C. Lessa,
Alice Guh
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0240549
Subject(s) - clostridioides , medicine , clostridium difficile , viral infection , virology , microbiology and biotechnology , biology , antibiotics , virus
We assessed viral co-infections in 155 patients with community-associated Clostridioides difficile infection in five U.S. sites during December 2012–February 2013. Eighteen patients (12%) tested positive for norovirus (n = 10), adenovirus (n = 4), rotavirus (n = 3), or sapovirus (n = 1). Co-infected patients were more likely than non-co-infected patients to have nausea or vomiting (56% vs 31%; p = 0.04), suggesting that viral co-pathogens contributed to symptoms in some patients. There were no significant differences in prior healthcare or medication exposures or in CDI complications.