Open AccessOmega-3 fatty acid supplement use and oxidative stress levels in pregnancy
Author(s) -
Erin G. Sley,
Emma M. Rosen,
Thomas J. van ‘t Erve,
Sheela Sathyanarayana,
Emily S. Barrett,
Ruby H.N. Nguyen,
Nicole R. Bush,
Ginger L. Milne,
Shanna H. Swan,
Kelly K. Ferguson
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0240244
Subject(s) - oxidative stress , pregnancy , medicine , metabolite , biomarker , confidence interval , confounding , prospective cohort study , endocrinology , urinary system , physiology , chemistry , biology , biochemistry , genetics
Oxidative stress is a biological imbalance in reactive oxygen species and antioxidants. Increased oxidative stress during pregnancy has been associated with adverse birth outcomes. Omega-3 fatty acid (n-3 FA) supplementation may decrease oxidative stress; however, this relationship is seldom examined during pregnancy. This study assessed the association between n-3 FA supplement use during pregnancy and urinary oxidative stress biomarker concentrations. Data came from The Infant Development and the Environment Study (TIDES), a prospective cohort study that recruited pregnant women in 4 US cities between 2010–2012. Third trimester n-3 FA intake was self-reported. Third trimester urinary 8-iso-prostaglandin F 2α (8-iso-PGF 2α ) was measured as an oxidative stress biomarker. Additionally, we measured the major metabolite of 8-iso-PGF 2α and Prostaglandin F 2α (PGF 2α ) and utilized the 8-iso-PGF 2α to PGF 2α ratio to calculate the change in 8-iso-PGF 2α reflecting oxidative stress versus inflammation. Adjusted linear models were used to determine associations with control for confounding. Of 725 women, 165 reported n-3 FA supplement use in the third trimester. In adjusted linear models, n-3 FA use was associated with 10.2% lower levels of 8-iso-PGF 2α (95% Confidence Interval [CI]: -19.6, 0.25) and 10.3% lower levels of the metabolite (95% CI: -17.1, -2.91). No associations were observed with PGF 2α . The lower levels of 8-iso-PGF 2α appeared to reflect a decrease in oxidative stress (percent change with supplement use: -18.7, 95% CI: -30.1, -5.32) rather than inflammation. Overall, third trimester n-3 FA intake was associated with lower concentrations of 8-iso-PGF 2α and its metabolite, suggesting a decrease in maternal oxidative stress during pregnancy.