Open AccessLongitudinal association between mental health and future antibiotic prescriptions in healthy adults: Results from the LOHAS
Author(s) -
Kentaro Tochitani,
Shungo Yamamoto,
Tsukasa Kamitani,
Hajime Yamazaki,
Shunichi Fukuhara,
Yosuke Yamamoto
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0240236
Subject(s) - medicine , medical prescription , mental health , odds ratio , confounding , cohort study , cohort , confidence interval , comorbidity , logistic regression , psychiatry , pharmacology
Objectives To investigate the association of mental health and subjective physical functioning with future antibiotic prescriptions. Design Prospective cohort study. Setting A rural town in Japan. Participants Participants who completed the baseline survey (2008–2010) of the Locomotive Syndrome and Health Outcomes in the Aizu Cohort Study (LOHAS) were recruited. Participants were limited to those without comorbidities according to the Charlson comorbidity index. Participants using antibiotics at baseline were excluded. Mental health and physical functioning were assessed using the Mental Health and Physical Functioning domains of the Short-Form 12 Health Survey, and depressive symptoms were assessed using the Mental Health Inventories at baseline. Main outcome measures The main outcome was antibiotic prescriptions found in claims data during 1 year after the baseline survey. Results A total of 967 participants were included in the analysis, and 151 (15.6%) participants with at least one missing variable for the confounding factors were excluded, leaving 816 participants for the primary analysis. Among the 816 participants, 65 (8.0%) were newly prescribed at least one antibiotic during the 1-year follow-up period. The most frequently prescribed antibiotics were third-generation cephalosporins (44 prescriptions; 35.5%), macrolides (28 prescriptions; 22.6%), and quinolones (23 prescriptions; 18.6%). A multivariable logistic regression analysis showed an association between higher mental health scores and future antibiotic prescriptions (adjusted odds ratio [AOR], 1.40 per 1 standard deviation [SD] increase; 95% confidence interval [CI], 1.03–1.90), whereas no significant relationship was observed between Physical Functioning scores and future antibiotic prescriptions (AOR, 0.95 per 1 SD increase; 95% CI, 0.75–1.22). During the secondary analysis, adults with depressive symptoms were less likely to be prescribed antibiotics (AOR, 0.27; 95% CI, 0.11–0.70). Conclusions Better mental health was associated with increased future antibiotic prescriptions for healthy community-dwelling Japanese adults, suggesting that mentally healthier adults could be a target population for reducing antimicrobial use.