Open AccessInhA inhibitors have activity against non-replicating Mycobacterium tuberculosis
Author(s) -
Lindsay Flint,
Aaron Korkegian,
Tanya Parish
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0239354
Subject(s) - inha , mycobacterium tuberculosis , tuberculosis , isoniazid , biology , microbiology and biotechnology , in vivo , medicine , genetics , pathology
We previously identified a diazaborine series with potential for development as a new tuberculosis drug. This series has activity in vitro and in vivo and targets cell wall biosynthesis via inhibition of InhA. The overall aim of this study was to determine whether InhA inhibitors have activity against non-replicating Mycobacterium tuberculosis . We tested the ability of two molecules of the diazaborine series to kill non-replicating M . tuberculosis in the nutrient starvation model; both molecules were bactericidal, reducing viability by >3 logs in 21 days. Activity showed similar kill rates to other InhA inhibitors (isoniazid and NITD-916). We conclude that inhibition of InhA is bactericidal against nutrient-starved non-replicating M . tuberculosis .