Open AccessMaternal supplementation with Bifidobacterium breve M-16V prevents their offspring from allergic airway inflammation accelerated by the prenatal exposure to an air pollutant aerosol
Author(s) -
Chiyoko Terada-Ikeda,
Masahiro Kitabatake,
Akari Hiraku,
Koichi Kato,
Satsuki Yasui,
Natsuko Imakita,
Noriko Ouji-Sageshima,
Noriyuki Iwabuchi,
Kaoru Hamada,
Toshihiro Ito
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0238923
Subject(s) - offspring , immunology , bifidobacterium breve , medicine , population , bronchoalveolar lavage , probiotic , bifidobacterium , pregnancy , biology , lung , lactobacillus , food science , genetics , environmental health , fermentation , bacteria
Bifidobacterium breve M-16V is a probiotic bacterial strain with efficacy in infants achieved by suppressing T-helper type (Th) 2 immune responses and modulating the systemic Th1/Th2 balance. Exposure to air pollution during pregnancy increases asthma susceptibility in offspring. The aim of this study was to investigate the effects of the maternal intake of B . breve M-16V on susceptibility to asthma accelerated by prenatal exposure to air pollution. The intake of B . breve M-16V in residual oil fly ash (ROFA)-exposed pregnant mice resulted in fewer eosinophils in the bronchoalveolar lavage fluid of neonatal mice and reduced allergic lung inflammation. The expressions of Th2 cytokines including IL-5 and IL-13 were decreased in neonatal mice from ROFA-exposed mothers fed B . breve M-16V. The analysis of fecal microbiota from neonatal mice revealed that the intake of B . breve M-16V by mothers changed the composition of fecal microbiota in neonatal mice, which resulted in a decreased population of Firmicutes . Moreover, several bacterial strains of fecal microbiota from neonatal mice had a strong correlation with Th2 cytokines and histological score. These results suggest that the maternal intake of M-16V might have beneficial effects in neonates by preventing and/or alleviating allergic reactions accelerated by prenatal exposure to air pollution.