Open AccessProgressive active mobilization with dose control and training load in critically ill patients (PROMOB): Protocol for a randomized controlled trial
Author(s) -
Rodrigo Santos de Queiroz,
Micheli Bernardone Saquetto,
Bruno Prata Martinez,
Bianca Bigogno Reis Cazeta,
Carol Hodgson,
Mansueto GomesNeto
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0238352
Subject(s) - medicine , randomized controlled trial , mechanical ventilation , physical therapy , intensive care unit , protocol (science) , incidence (geometry) , clinical trial , intensive care , physical medicine and rehabilitation , emergency medicine , intensive care medicine , surgery , anesthesia , physics , alternative medicine , pathology , optics
The dose of progressive active mobilization is still uncertain. The purpose of this study is to identify if the addition of a protocol of progressive active mobilization with dose and training load control to usual care is effective in reducing the length of stay in intensive care unit (ICU) and the improvement of the functioning, incidence of ICU-acquired weakness (ICUAW), mechanical ventilation duration and mortality rate in patients hospitalized in ICU. It is Double-blind randomised clinical trial. The setting for this trial will be medical and surgical ICU of a university hospital. The study participants will be 118 patients aged> 18 years admitted to ICU for less than 72 hours. Participants will be randomized to either an experimental or control group. The experimental group will undertake addition of a protocol of progressive active mobilization with dose and training load control to usual care, while the control group will undertake only usual care. The primary outcome will be length of ICU stay. The secondary outcomes will be Cross-sectional area and muscle thickness of the rectus femoris and biceps brachii, Change in muscle strength from the baseline, Functional Status, incidence of ICUAW, Days with mechanical ventilation and Mortality. All statistical analyses will be conducted following intention-to-treat principles. It has a detailed description of the dose of exercise, was designed with the strictest methodological criteria. These characteristics allow to investigate with greater certainty the results progressive active mobilization in critical patients, allowing replication and future combinations in meta-analyzes.