Open AccessSensitivity and specificity of high-resolution wide field fundus imaging for detecting neovascular age-related macular degeneration
Author(s) -
Maiko Maruyama-Inoue,
Yoko Kitajima,
Shaheeda Mohamed,
Tatsuya Inoue,
Shimpei Sato,
Arisa Ito,
Shin Yamane,
Kazuaki Kadonosono
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0238072
Subject(s) - macular degeneration , medicine , fundus (uterus) , fundus photography , ophthalmology , choroidal neovascularization , fluorescein angiography , visual acuity
Purpose Early detection and treatment are important management strategies for neovascular age-related macular degeneration (AMD). The purpose of this study was to determine the sensitivity and specificity in detecting neovascular AMD using two wide-field imaging systems: Clarus TM (CLARUS 500™, Carl Zeiss Meditec AG, Jena, Germany) and Optos ® (Optos California ® , Optos PLC, Dunfermline, United Kingdom), compared to conventional digital fundus photographs. Methods We retrospectively analyzed 109 eyes of 73 consecutive patients with neovascular AMD, who underwent standard examination and multimodal imaging, including fundus photography, and optical coherence tomography (OCT). Unmasked graders utilized slit-lamp biomicroscopy and OCT to diagnose neovascular AMD. Masked graders evaluated Clarus TM , Optos ® , and digital fundus photograph methods to determine the presence of choroidal neovascularization associated with AMD. Sensitivity and specificity analyses were performed using combined fundoscopy and OCT as the reference standard. Results Ninety eyes were diagnosed with neovascular AMD and the remaining 19 eyes were normal based on the reference standard. Of these, neovascular AMD was detected using Clarus TM in 94.4% (85/90). The sensitivities of Optos ® and digital fundus photographs were 81.1% (73/90) and 87.8% (79/90), respectively. The specificities using Clarus TM , Optos ® , and digital fundus photographs were 89.5% (17/19), 94.7% (18/19), and 89.5% (17/19), respectively. Conclusion Clarus TM , with its ability to image high-resolution wide field fundus, was considered superior for diagnosing neovascular AMD with high sensitivity and specificity. It may be a useful screening tool for early detection of neovascular AMD, facilitating prompt referral and treatment.