Open AccessDecreased incidence, virus transmission capacity, and severity of COVID-19 at altitude on the American continent
Author(s) -
Christian AriasReyes,
Favio Carvajal-Rodriguez,
Liliana Poma-Machicao,
Fernanda AliagaRaduán,
Danuzia A. Marques,
Natalia Zubieta-DeUrioste,
Roberto A. Accinelli,
Edith M. SchneiderGasser,
Gustavo Zubieta-Calleja,
Mathias Dutschmann,
Jorge Soliz
Publication year - 2021
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0237294
Subject(s) - outbreak , altitude (triangle) , pandemic , epidemiology , transmission (telecommunications) , covid-19 , incidence (geometry) , demography , effects of high altitude on humans , geography , virus , coronavirus , veterinary medicine , biology , medicine , virology , disease , infectious disease (medical specialty) , meteorology , physics , geometry , mathematics , optics , sociology , electrical engineering , engineering
The coronavirus disease 2019 (COVID-19) outbreak in North, Central, and South America has become the epicenter of the current pandemic. We have suggested previously that the infection rate of this virus might be lower in people living at high altitude (over 2,500 m) compared to that in the lowlands. Based on data from official sources, we performed a new epidemiological analysis of the development of the pandemic in 23 countries on the American continent as of May 23, 2020. Our results confirm our previous finding, further showing that the incidence of COVID-19 on the American continent decreases significantly starting at 1,000 m above sea level (masl). Moreover, epidemiological modeling indicates that the virus transmission rate is lower in the highlands (>1,000 masl) than in the lowlands (<1,000 masl). Finally, evaluating the differences in the recovery percentage of patients, the death-to-case ratio, and the theoretical fraction of undiagnosed cases, we found that the severity of COVID-19 is also decreased above 1,000 m. We conclude that the impact of the COVID-19 decreases significantly with altitude.