Open AccessVitamin D status, nutrition and growth in HIV-infected mothers and HIV-exposed infants and children in Botswana
Author(s) -
Alyssa Tindall,
Joan I. Schall,
Boitshepo Seme,
Bakgaki Ratshaa,
Michael A. Tolle,
Maria Nnyepi,
Loeto Mazhani,
Richard M. Rutstein,
Andrew P. Steenhoff,
Virginia A. Stallings
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0236510
Subject(s) - breastfeeding , medicine , vitamin d and neurology , human immunodeficiency virus (hiv) , vitamin , viral load , pediatrics , vitamin d deficiency , pregnancy , cross sectional study , breast feeding , physiology , immunology , biology , pathology , genetics
Background Poor vitamin D status is a global health problem and common in patients with human immunodeficiency virus (HIV) in high-income countries. There is less evidence on prevalence of vitamin D deficiency and nutrition and growth in HIV-infected and -exposed children in low- and middle-income countries. Objectives To determine the vitamin D status in Batswana HIV-infected mothers and their children, differences among HIV-infected mothers and between HIV-exposed and -infected infants and children, and associations between vitamin D and disease-related outcomes, nutrition, and growth. Methods This was a cross-sectional study of HIV+ mothers and HIV-exposed infants and unrelated children (1–7.9 years). Serum 25-hydroxyvitamin D (25(OH)D) was measured, among other nutritional indicators, for mothers, infants and children. Vitamin D status for HIV-infected mothers and children, and an immune panel was assessed. History of HIV anti-retroviral medications and breastfeeding were obtained. Data were collected prior to universal combination antiretroviral therapy in pregnancy. Results Mothers ( n = 36) had a mean serum 25(OH)D of 37.2±12.4ng/mL; 11% had insufficient (<20ng/mL), 17% moderately low (20.0–29.9ng/mL) and 72% sufficient (≥30ng/mL) concentrations. No infants ( n = 36) or children ( n = 48) were vitamin D insufficient; 22% of HIV- and no HIV+ infants had moderately low concentrations and 78% of HIV- and 100% of HIV+ infants had sufficient status, 8% of HIV- and no HIV+ children had moderately low concentrations and 92% of HIV- and 100% HIV+ children had sufficient concentrations. HIV+ children had significantly lower length/height Z scores compared to HIV- children. Length/height Z score was positively correlated with serum 25(OH)D in all children (r = 0.33, p = 0.023), with a stronger correlation in the HIV+ children (r = 0.47 p = 0.021). In mothers, serum 25(OH)D was positively associated with CD4% (r = 0.40, p = 0.016). Conclusions Results showed a low prevalence of vitamin D insufficiency in Botswana. Growth was positively correlated with vitamin D status in HIV-exposed children, and HIV+ children had poorer linear growth than HIV- children.