Open AccessUndefeated—Changing the phenamacril scaffold is not enough to beat resistant Fusarium
Author(s) -
Rasmus Dam Wollenberg,
Søren Sejer Donau,
Manuel H. Taft,
Zoltán Balázs,
Sven Giese,
Claudia Thiel,
Jens Laurids Sørensen,
Thorbjørn Terndrup Nielsen,
Henriette Giese,
Dietmar J. Manstein,
Reinhard Wimmer,
Teis Esben Søndergaard
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0235568
Subject(s) - fusarium , fungicide , biology , scaffold , botany , microbiology and biotechnology , biomedical engineering , medicine
Filamentous fungi belonging to the genus Fusarium are notorious plant-pathogens that infect, damage and contaminate a wide variety of important crops. Phenamacril is the first member of a novel class of single-site acting cyanoacrylate fungicides which has proven highly effective against important members of the genus Fusarium . However, the recent emergence of field-resistant strains exhibiting qualitative resistance poses a major obstacle for the continued use of phenamacril. In this study, we synthesized novel cyanoacrylate compounds based on the phenamacril-scaffold to test their growth-inhibitory potential against wild-type Fusarium and phenamacril-resistant strains. Our findings show that most chemical modifications to the phenamacril-scaffold are associated with almost complete loss of fungicidal activity and in vitro inhibition of myosin motor domain ATPase activity.