Open AccessGenetic polymorphisms of superoxide dismutase 1 are associated with the serum lipid profiles of Han Chinese adults in a sexually dimorphic manner
Author(s) -
Ping Xu,
Yong Zhu,
Xiongshun Liang,
Chunmei Gong,
Yuanfei Xu,
Changhua Huang,
Xiaoli Liu,
Jinchuan Zhou
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0234716
Subject(s) - dyslipidemia , single nucleotide polymorphism , sexual dimorphism , medicine , biology , genotype , lipid profile , superoxide dismutase , endocrinology , physiology , genetics , cholesterol , obesity , oxidative stress , gene
Inspired by the mechanistic correlations between superoxide dismutase 1 (SOD1) and lipid metabolism, the associations of SOD1 single nucleotide polymorphisms (SNPs) with circulating lipid levels were explored. In 2621 Chinese Han adults, randomly recruited from a health examination center without organic diseases, cancers, and pregnancy, three tag SNPs, rs4998557, rs1041740, and rs17880487 selected by Haploview software were genotyped with a probe-based real-time quantitative PCR method. In both genders, most parameters of the dyslipidemia adults were inferior ( P < 0.001) to those of the non-dyslipidemia adults, and genotype frequencies of rs4998557 and rs17880487 were significantly different ( P < 0.05) between the normal and abnormal subgroups of total cholesterol (TC) or high-density lipoprotein cholesterol (HDLC). Adjusted for confounding factors, logistic regression analyses revealed that in males rs4998557A, rs1041740T, and rs17880487T reduced the risk of high TC and/or LDLC ( P < 0.05), and rs4998557A and rs17880487T increased the risk of low HDLC ( P < 0.05); but in females, none of the SNPs had associations with any of the lipid parameters ( P > 0.05). Conclusively, characterized by a sexual dimorphism, the SOD1 polymorphisms were associated with the lipid disorders in the adult males but not females of the Chinese Han population.