Open AccessLung aeration in experimental malaria-associated acute respiratory distress syndrome by SPECT/CT analysis
Author(s) -
Thatyane de Castro Quirino,
Luana dos Santos Ortolan,
Michelle Klein Sercundes,
Cláudio Romero Farias Marinho,
Walter Miguel Turato,
Sabrina Epiphânio
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0233864
Subject(s) - ards , medicine , lung , hypoxemia , diffuse alveolar damage , pathology , respiratory distress , quantitative computed tomography , vascular permeability , pulmonary edema , pleural effusion , radiology , acute respiratory distress , osteoporosis , bone density
Malaria-associated acute respiratory distress syndrome (ARDS) is an inflammatory disease causing alveolar-pulmonary barrier lesion and increased vascular permeability characterized by severe hypoxemia. Computed tomography (CT), among other imaging techniques, allows the morphological and quantitative identification of lung lesions during ARDS. This study aims to identify the onset of malaria-associated ARDS development in an experimental model by imaging diagnosis. Our results demonstrated that ARDS-developing mice presented decreased gaseous exchange and pulmonary insufficiency, as shown by the SPECT/CT technique. The pulmonary aeration disturbance in ARDS-developing mice on the 5 th day post infection was characterized by aerated tissues decrease and nonaerated tissue accumulation, demonstrating increased vascular permeability and pleural effusion. The SPECT/CT technique allowed the early diagnosis in the experimental model, as well as the identification of the pulmonary aeration. Notwithstanding, despite the fact that this study contributes to better understand lung lesions during malaria-associated ARDS, further imaging studies are needed.