Open AccessEvaluation of proton beam radiation-induced skin injury in a murine model using a clinical SOBP
Author(s) -
Pietro Pisciotta,
Angelita Costantino,
Francesco Paolo Cammarata,
Filippo Torrisi,
Giovanna Calabrese,
Valentina Marchese,
G.A.P. Cirrone,
Giada Petringa,
Giusi Irma Forte,
Luigi Minafra,
Valentina Bravatà,
Massimo Gulisano,
Fabrizio Scopelliti,
Francesco Tommasino,
Emanuele Scifoni,
G. Cuttone,
Massimo Ippolito,
Rosalba Parenti,
Giorgio Russo
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0233258
Subject(s) - sobp , medicine , bragg peak , nuclear medicine , proton , irradiation , radiation therapy , surgery , proton therapy , physics , quantum mechanics , nuclear physics
The purpose of this paper is to characterize the skin deterministic damage due to the effect of proton beam irradiation in mice occurred during a long-term observational experiment. This study was initially defined to evaluate the insurgence of myelopathy irradiating spinal cords with the distal part of a Spread-out Bragg peak (SOBP). To the best of our knowledge, no study has been conducted highlighting high grades of skin injury at the dose used in this paper. Nevertheless these effects occurred. In this regard, the experimental evidence of significant insurgence of skin injury induced by protons using a SOBP configuration will be shown. Skin damages were classified into six scores (from 0 to 5) according to the severity of the injuries and correlated to ED50 (i.e. the radiation dose at which 50% of animals show a specific score) at 40 days post-irradiation (d.p.i.). The effects of radiation on the overall animal wellbeing have been also monitored and the severity of radiation-induced skin injuries was observed and quantified up to 40 d.p.i.