Open AccessClinical characteristics and long-term evolution of lamellar macular hole in high myopia
Author(s) -
Yun Hsia,
TzyyChang Ho,
ChangHao Yang,
YiTing Hsieh,
TsoTing Lai
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0232852
Subject(s) - term (time) , macular hole , lamellar structure , medicine , optometry , ophthalmology , physics , materials science , visual acuity , astronomy , vitrectomy , composite material
Purpose To evaluate the clinical characteristics and evolution of lamellar macular hole (LMH) in high myopia and the parameters associated with structural worsening, defined as the development of foveal detachment or full-thickness macular hole. Methods Patients with high myopia and LMH were retrospectively recruited. The clinical characteristics and various parameters of optical coherence tomography were identified at baseline and during follow-up visits. Cox regression analysis was used to evaluate the hazard ratios for foveal detachment and full-thickness macular hole. Results Among 112 eyes (98 patients), 64.3% were female; the mean axial length of all eyes was 29.6 ± 1.9 mm. The ‘LMH without retinoschisis’ group accounted for 39.3% of the eyes. Forty-two percent developed structural worsening within a median follow-up of 67 months. Multivariable regression on all cases showed elevated tissue inside the LMH ( P = 0.003) protected against structural worsening while V-shaped LMH ( P = 0.006) predicted it. In the “LMH with retinoschisis group”, ellipsoid zone disruption ( P = 0.035), and V-shaped LMH ( P = 0.014) predicted structural worsening, while elevated tissue inside the LMH ( P = 0.028) protected against it. In the “LMH without retinoschisis group”, no associated factor was identified. Conclusions LMHs in high myopia are unstable, especially those with V-shaped LMH. Elevated tissue inside LMHs have a protective effect against further structural worsening.