Open AccessIncidence and risk factors for hyperglycemia in pregnancy among nulliparous women: A Brazilian multicenter cohort study
Author(s) -
Bianca Fioravanti Nicolosi,
Renato T. Souza,
Jussara Mayrink,
Francisco Edson de Lucena Feitosa,
Edilberto A. Rocha Filho,
Débora Farias Batista Leite,
Janete Vettorazzi,
Maria Helena de Sousa,
Maria Laura Costa,
Philip N. Baker,
Louise C. Kenny,
José Guilherme Cecatti,
Iracema de Mattos Paranhos Calderon
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0232664
Subject(s) - medicine , gestational diabetes , overweight , obstetrics , pregnancy , incidence (geometry) , diabetes mellitus , cohort , body mass index , cohort study , obesity , gestation , endocrinology , biology , genetics , physics , optics
Objective To assess the incidence and risk factors for hyperglycemia in pregnancy in a cohort of Brazilian nulliparous pregnant women. Materials and methods This is a secondary analysis of a multicenter cohort study that enrolled 1,008 nulliparous pregnant women at 19–21 weeks. Exclusion criteria included chronic exposure to corticosteroids and previous diabetes. Bivariate and multivariate analyses by Poisson regression were used to identify associated factors. Results The incidence of hyperglycemia in pregnancy was 14.9% (150/1,008), and 94.7% of these cases were gestational diabetes mellitus (142/150). Significant associated factors included a family history of diabetes mellitus, maternal overweight or obesity at enrollment, and previous maternal conditions (polycystic ovarian syndrome, thyroid dysfunctions and hypertensive disorders). A BMI ≥ 26.3Kg/m 2 (RR adj 1.87 [1.66–2.10]) and a family history of diabetes mellitus (RR adj 1.71 [1.37–2.15]) at enrollment were independent risk factors for HIP. Conclusions A family history of diabetes mellitus and overweight or obesity (until 19–21 weeks of gestation) may be used as selective markers for HIP in Brazilian nulliparous women. Given the scarcity of results in nulliparous women, our findings may contribute to determine the optimal diagnostic approach in populations of similar socioeconomic characteristics.