Open AccessRegulatory effects of Lactobacillus plantarum HY7714 on skin health by improving intestinal condition
Author(s) -
Bora Nam,
SooA Kim,
Soo Dong Park,
Hyeon Ji Kim,
Ji Soo Kim,
Chu Hyun Bae,
Joo Yun Kim,
Woo Dong Nam,
Jung Lyoul Lee,
Jae-Il Sim
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0231268
Subject(s) - lactobacillus plantarum , bifidobacterium , downregulation and upregulation , calprotectin , immune system , probiotic , biology , microbiology and biotechnology , lactobacillus , immunology , medicine , bacteria , gene , inflammatory bowel disease , disease , biochemistry , lactic acid , genetics
Despite increasing research on the gut-skin axis, there is a lack of comprehensive studies on the improvement of skin health through the regulation of the intestinal condition in humans. In this study, we investigated the benefits of Lactobacillus plantarum HY7714 (HY7714) consumption on skin health through its modulatory effects on the intestine and ensuing immune responses. HY7714 consumption led to differences in bacterial abundances from phylum to genus level, including increases in Actinobacteria followed by Bifidobacterium and a decrease in Proteobacteria. Additionally, HY7714 significantly ameliorated inflammation by reducing matrix metallopeptidases (MMP-2 and MMP-9), zonulin, and calprotectin in plasma, all of which are related to skin and intestinal permeability. Furthermore, RNA-seq analysis revealed its efficacy at restoring the integrity of the gut barrier by regulating gene expression associated with the extracellular matrix and immunity. This was evident by the upregulation of IGFBP5, SERPINE1, EFEMP1, COL6A3, and SEMA3B and downregulation of MT2A, MT1E, MT1X, MT1G, and MT1F between TNF- α and TNF- α plus HY7714 treated Caco-2 cells. These results propose the potential mechanistic role of HY7714 on skin health by the regulation of the gut condition.