Open AccessInterferon gamma-induced protein 10 (IP-10) and cardiovascular disease in African Americans
Author(s) -
Colton Leavitt,
Neil A. Zakai,
Paul L. Auer,
Mary Cushman,
Ethan M. Lange,
Emily B Levitan,
Nels C. Olson,
Timothy A. Thornton,
Russell P. Tracy,
James G. Wilson,
Leslie A. Lange,
Alex P. Reiner,
Laura M. Raffield
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0231013
Subject(s) - medicine , hazard ratio , odds ratio , heart failure , stroke (engine) , c reactive protein , cardiology , coronary artery disease , cohort , confidence interval , inflammation , mechanical engineering , engineering
Biomarkers of chronic inflammation (such as C-reactive protein) have long been associated with cardiovascular disease and mortality; however, biomarkers involved in antiviral cytokine induction and adaptive immune system activation remain largely unexamined. We hypothesized the cytokine interferon gamma inducible protein 10 (IP-10) would be associated with clinical and subclinical cardiovascular disease and all-cause mortality in African Americans. We assessed these associations in the Jackson Heart Study (JHS) cohort and the REasons for Geographic and Racial Differences in Stroke (REGARDS) study. There was a modest association of IP-10 with higher odds of left ventricular hypertrophy (OR = 1.20 (95% confidence interval (CI) 1.03, 1.41) per standard deviation (SD) higher natural log-transformed IP-10 in JHS). We did not observe associations with ankle brachial index, intima-media thickness, or arterial calcification. Each SD higher increment of ln-transformed IP-10 concentration was associated with incident heart failure (hazard ratio (HR) 1.26; 95% CI 1.11, 1.42, p = 4x10 -4 ) in JHS, and with overall mortality in both JHS (HR 1.12 per SD, 95% CI 1.03, 1.21, p = 7.5x10 -3 ) and REGARDS (HR 1.31 per SD, 95% CI 1.10, 1.55, p = 2.0 x 10 −3 ), adjusting for cardiovascular risk factors and C-reactive protein. However, we found no association between IP-10 and stroke or coronary heart disease. These results suggest a role of IP-10 in heart failure and mortality risk independent of C-reactive protein. Further research is needed to investigate how the body’s response to chronic viral infection may mediate heart failure and overall mortality risk in African Americans.