Open AccessReduced Clostridioides difficile infection in a pragmatic stepped-wedge initiative using admission surveillance to detect colonization
Author(s) -
Lance R. Peterson,
Sean O’Grady,
Mary Keegan,
Adrienne Fisher,
Shane Zelencik,
Bridget Kufner,
Mona Shah,
Rachel Lim,
Donna Schora,
Sanchita Das,
Kamaljit Singh
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0230475
Subject(s) - medicine , clostridioides , incidence (geometry) , infection control , diarrhea , emergency medicine , psychological intervention , pediatrics , intensive care medicine , physics , optics , psychiatry
Background Clostridioides difficile Infection (CDI) is a persistent healthcare issue. In the US, CDI is the most common infectious cause of hospital-onset (HO) diarrhea. Objective Assess the impact of admission testing for toxigenic C . difficile colonization on the incidence of HO-CDI. Design Pragmatic stepped-wedge Infection Control initiative. Setting NorthShore University HealthSystem is a four-hospital system near Chicago, IL. Patients All patients admitted to the four hospitals during the initiative. Interventions From September 2017 through August 2018 we conducted a quality improvement program where admitted patients had a peri-rectal swab tested for toxigenic C . difficile . All colonized patients were placed into contact precautions. Measurements We tested admissions who: i ) had been hospitalized within two months, ii ) had a past C . difficile positive test, and/or iii ) were in a long-term care facility within six months. We measured compliance with all other practices to reduce the incidence of HO-CDI. Results 30% of admissions were tested and 8.3% were positive. In the year prior to the initiative (Period 1) there were 63,057 admitted patients when HO-CDI incidence was 5.96 cases/10,000 patient days. During the 12-month initiative (Period 2) there were 62,760 admissions and the HO-CDI incidence was 4.23 cases/10,000 patient days ( p = 0.02). There were no other practice or antibiotic use changes. Continuing admission surveillance provided a HO-CDI incidence of 2.9 cases/10,000 patient days during the final 9 months of 2018 ( p <0.0001 compared to Period 1), equaling <1 case/1,000 admissions. Limitations This was not a randomized controlled trial, and multiple prevention practices were in place at the time of the admission surveillance initiative. Conclusion Admission C . difficile surveillance testing is an important tool for preventing hospital-onset C . difficile infection. Registration This quality improvement initiative is registered at ClinicalTrials.gov. The unique registration identifier number is NCT04014608 .