Open AccessOnset of brain injury in infants with prenatally diagnosed congenital heart disease
Author(s) -
Mirthe J Mebius,
C. M. Bilardo,
Martin C. J. Kneyber,
Marco Modestini,
Tjark Ebels,
Rolf M. F. Berger,
Arend F. Bos,
Elisabeth M. W. Kooi
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0230414
Subject(s) - medicine , middle cerebral artery , umbilical artery , fetus , pediatrics , heart disease , cerebral blood flow , pregnancy , cardiology , ischemia , biology , genetics
Background The exact onset of brain injury in infants with congenital heart disease (CHD) is unknown. Our aim was, therefore, to assess the association between prenatal Doppler flow patterns, postnatal cerebral oxygenation and short-term neurological outcome. Methods Prenatally, we measured pulsatility indices of the middle cerebral (MCA-PI) and umbilical artery (UA-PI) and calculated cerebroplacental ratio (CPR). After birth, cerebral oxygen saturation (r c SO 2 ) and fractional tissue oxygen extraction (FTOE) were assessed during the first 3 days after birth, and during and for 24 hours after every surgical procedure within the first 3 months after birth. Neurological outcome was determined preoperatively and at 3 months of age by assessing general movements and calculating the Motor Optimality Score (MOS). Results Thirty-six infants were included. MOS at 3 months was associated with MCA-PI (rho 0.41, P = 0.04), UA-PI (rho -0.39, P = 0.047, and CPR (rho 0.50, P = 0.01). Infants with abnormal MOS had lower MCA-PI ( P = 0.02) and CPR ( P = 0.01) and higher UA-PI at the last measurement ( P = 0.03) before birth. In infants with abnormal MOS, r c SO 2 tended to be lower during the first 3 days after birth, and FTOE was significantly higher on the second day after birth ( P = 0.04). Intraoperative and postoperative r c SO 2 and FTOE were not associated with short-term neurological outcome. Conclusion In infants with prenatally diagnosed CHD, the prenatal period may play an important role in developmental outcome. Additional research is needed to clarify the relationship between preoperative, intra-operative and postoperative cerebral oxygenation and developmental outcome in infants with prenatally diagnosed CHD.