Open AccessFrailty, markers of immune activation and oxidative stress in HIV infected elderly
Author(s) -
Susana Álvarez,
Fátima Brañas,
Matilde Sánchez-Conde,
Santiago Moreno,
Juan Carlos López-Bernaldo de Quirós,
María Ángeles MuñozFernández
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0230339
Subject(s) - immunosenescence , immune system , cd8 , immunology , cd38 , cd28 , senescence , oxidative stress , immune dysregulation , population , t cell , biology , cd3 , medicine , gerontology , stem cell , microbiology and biotechnology , cd34 , environmental health
People living with HIV-1 experience an accelerated aging due to the persistent and chronic activation of the immune system. This phenomenon conduces to immune exhaustion and precipitate immunosenescence. In general, frailty is defined as a syndrome of physiological degeneration in the elderly. Circulating naïve and memory T cells were studied by flow cytometry in non-frail and frail HIV-1-infected groups. Thymopoiesis, cell activation, senescence and cell proliferation were analyzed by CD31, HLA-DR/CD38, CD28/CD57 and Ki-67 expression, respectively. Plasma levels of sCD14 and MDA were measured by ELISA. Frail infected individuals showed a reduced number of memory T cells, both CD4 + and CD8 + populations. Activated CD3 + CD4 + HLA-DR + T cells were lower in frail individuals, and directly correlated with CD3 + CD8 + HLA-DR + and CD8 M cells. Senescent CD8 + CD28 − CD57 + cells were reduced in frail HIV-1 infected individuals and inversely correlated with CD8 RTE , CD8 N and CD3 + CD4 + HLA-DR + . Higher plasma levels of sCD14 and MDA were found in HIV-1 infected frail individuals. Our data show association among frailty, markers of immune activation and oxidative stress. Understanding the immune mechanisms underlying frailty status in HIV-1 population is of high relevance not only for the prediction of continuing longevity but also for the identification of potential strategies for the elderly.