Open AccessPerinatal HCV Transmission Rate in HIV/HCV Coinfected women with access to ART in Madrid, Spain
Author(s) -
Sara DomínguezRodríguez,
Luís Prieto,
Carolina Fernández McPhee,
Marta Illán Ramos,
José Beceiro,
Luis Escosa,
Eloy Muñoz,
Iciar Olabarrieta,
Francisco Javier Regidor,
Miguel Ángel Roa,
María Del Carmen Viñuela Benéitez,
Sara Guillén,
María Luisa Navarro-Gómez,
José Tomás Ramos Amador
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0230109
Subject(s) - coinfection , medicine , cohort , transmission (telecommunications) , hepatitis c , retrospective cohort study , pregnancy , epidemiology , cohort study , obstetrics , pediatrics , immunology , human immunodeficiency virus (hiv) , biology , electrical engineering , genetics , engineering
Background Maternal HIV coinfection is a key factor for mother-to-child transmission (MTCT) of HCV. However, data about HCV MTCT in HIV/HCV-coinfected pregnant women on combined antiretroviral treatment (ART) are scarce. This study assessed the HCV MTCT rate in the Madrid Cohort of HIV-infected women. Methods Retrospective study within the Madrid Cohort of HIV-infected pregnant women (2000–2012). Epidemiological, clinical and treatment related variables were analysed for the mother and infant pairs. HCV MTCT rate was determined. Results Three hundred thirty-nine HIV/HCV-coinfected women and their exposed infants were recorded. A total of 227 (67%) paired mother-children had available data of HCV follow-up and were included for the analysis. Sixteen children (rate 7.0%, 95%CI 3.7–10.4%) were HCV infected by 18 months of age, none of them coinfected with HIV. HIV/HCV-coinfected pregnant women were mostly of Spanish origin with a background of previous injection drug use. HCV-genotype 1 was predominant. The characteristics of mothers that transmitted HCV were similar to those that did not transmit HCV with respect to sociodemographic and clinical features. A high rate (50%) of preterm deliveries was observed. Infants infected with HCV were similar at birth in weight, length and head circumference than those uninfected. Conclusion MTCT rates of HCV among HIV/HCV-coinfected women on ART within the Madrid cohort were lower than previously described. However, rates are still significant and strategies to eliminate any HCV transmission from mother to child are needed.