Open AccessA facile sonochemical protocol for synthesis of 3-amino- and 4-amino-1,2,4-triazole derived Schiff bases as potential antibacterial agents
Author(s) -
Aeysha Sultan,
Mian Habib Ur Rehman,
Noreen Sajjad,
Ali Irfan,
Irfan Ullah,
Muhammad Mustaqeem,
Muhammad Saleem,
Syeda Laila Rubab,
Muhammad Rafiq,
Muhammad Khalid,
Katarzyna Kotwica-Mojzych,
Mariusz Mojzych
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0229891
Subject(s) - bacillus subtilis , chemistry , escherichia coli , schiff base , shigella , staphylococcus aureus , pseudomonas aeruginosa , combinatorial chemistry , antibacterial activity , shigella sonnei , amino acid , microbiology and biotechnology , bacteria , stereochemistry , biology , biochemistry , genetics , gene
A facile method has been developed for the synthesis of Schiff bases derived from substituted and unsubstituted 3-amino- and 4-amino-1,2,4-triazoles. Condensation of the aminotrizoles with a variety of aromatic aldehydes afforded desired Schiff bases in excellent yields in 3–5 minutes of exposure to ultra-sound. The synthesized compounds were characterized by means of IR, 1 HNMR and Mass spectrometry. The synthesized compounds were also screened for their antibacterial potential against Gram-negative ( Escherichia coli , Shigella sonnei , Pseudomonas aeruginosa and Salmonella typhi ) and two Gram-positive ( Staphylococcus aureus and Bacillus subtilis) strains.