Open AccessResistance exercise causes greater serum hepcidin elevation than endurance (cycling) exercise
Author(s) -
Kazushige Goto,
Chihiro Kojima,
Nobukazu Kasai,
Daichi Sumi,
Nanako Hayashi,
HyeonJong Hwang
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0228766
Subject(s) - hepcidin , medicine , endocrinology , endurance training , exercise physiology , inflammation
Background Hepcidin is an iron regulating hormone, and exercise-induced hepcidin elevation is suggested to increase the risk of iron deficiency among athletes. Objective We compared serum hepcidin responses to resistance exercise and endurance (cycling) exercise. Methods Ten males [mean ± standard error: 172 ± 2 cm, body weight: 70 ± 2 kg] performed three trials: a resistance exercise trial (RE), an endurance exercise trial (END), and a rest trial (REST). The RE consisted of 60 min of resistance exercise (3−5 sets × 12 repetitions, 8 exercises) at 65% of one repetition maximum, while 60 min of cycling exercise at 65% ofV ˙ O 2 maxwas performed in the END. Blood samples were collected before exercise and during a 6-h post-exercise (0h, 1h, 2h, 3h, 6h after exercise). Results Both RE and END significantly increased blood lactate levels, with significantly higher in the RE ( P < 0.001). Serum iron levels were significantly elevated immediately after exercise ( P < 0.001), with no significant difference between RE and END. Both the RE and END significantly increased serum growth hormone (GH), cortisol, and myoglobin levels ( P < 0.01). However, exercise-induced elevations of GH and cortisol were significantly greater in the RE (trial × time: P < 0.001). Plasma interleukin-6 (IL-6) levels were significantly elevated after exercise ( P = 0.003), with no significant difference between the trials. Plasma hepcidin levels were elevated after exercise ( P < 0.001), with significantly greater in the RE (463 ± 125%) than in the END (137 ± 27%, P = 0.03). During the REST, serum hepcidin and plasma IL-6 levels did not change significantly. Conclusion Resistance exercise caused a greater exercise-induced elevation in hepcidin than did endurance (cycling) exercise. The present findings indicate that caution will be required to avoid iron deficiency even among athletes in strength (power) types of events who are regularly involved in resistance exercise.