Open AccessDifferential effects of aquaporin-4 channel inhibition on BOLD fMRI and diffusion fMRI responses in mouse visual cortex
Author(s) -
Yuji Komaki,
Clément Debacker,
Boucif Djemaï,
Luisa Ciobanu,
Tomokazu Tsurugizawa,
Denis Le Bihan
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0228759
Subject(s) - astrocyte , neuroscience , visual cortex , aquaporin 4 , functional magnetic resonance imaging , electrophysiology , cortex (anatomy) , psychology , medicine , pathology , central nervous system
The contribution of astrocytes to the BOLD fMRI and DfMRI responses in visual cortex of mice following visual stimulation was investigated using TGN-020, an aquaporin 4 (AQP4) channel blocker, acting as an astrocyte function perturbator. Under TGN-020 injection the amplitude of the BOLD fMRI response became significantly higher. In contrast no significant changes in the DfMRI responses and the electrophysiological responses were observed. Those results further confirm the implications of astrocytes in the neurovascular coupling mechanism underlying BOLD fMRI, but not in the DfMRI responses which remained unsensitive to astrocyte function perturbation.