Open AccessThe impact of diabetes mellitus medication on the incidence of endogenous endophthalmitis
Author(s) -
KeHung Chien,
Ke-Hao Huang,
ChiHsiang Chung,
Yun-Hsiu Hsieh,
Chang-Min Liang,
Yuhua Chang,
Tzu-Heng Weng,
Wu-Chien Chien
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0227442
Subject(s) - incidence (geometry) , diabetes mellitus , medicine , endophthalmitis , endogeny , intensive care medicine , ophthalmology , endocrinology , physics , optics
Purpose This study aimed to evaluate the relationship between diabetic mellitus (DM) treatment and the incidence rate of endogenous endophthalmitis (EE). Design This study used a matched cohort design. We utilized the Longitudinal Health Insurance Database to identify outpatients and inpatients who were diagnosed with DM and treated with medication from 2000 to 2010. Methods Several factors and different DM medications were also investigated. The influence of DM medication on the incidence of EE was examined by using Cox proportional hazards regression models, and the hazard ratios and 95% confidence intervals were determined. Results The cumulative incidence of EE was lower in DM patients treated with medication than in subjects in the control group (P = 0.002). The adjusted hazard ratio (AHR) was 0.47-fold lower in the treatment group than in the control group (P = 0.004). With respect to DM medication, single-agent therapy with insulin, metformin, gliclazide, glimepiride, or repaglinide and combination therapy with glimepiride/metformin or repaglinide/metformin were associated with decreased AHRs (0.257–0.544, all P<0.05). Conclusions Diabetic patients treated with medication had lower AHRs than those in the control group. Further stratification indicated that liver abscess, liver disease DM patients who were treated with medication had a lower risk of developing EE. Several specific DM medications may decrease the incidence of EE.