Open AccessTrends of the prevalence and incidence of hypertrophic cardiomyopathy in Korea: A nationwide population-based cohort study
Author(s) -
Inki Moon,
Seo-Young Lee,
Yong Jin Kim,
Kyungdo Han,
SeoYoung Kwak,
Minkwan Kim,
Hyunjung Lee,
InChang Hwang,
Heesun Lee,
JunBean Park,
Yeonyee E. Yoon,
Yong-Jin Kim,
Goo-Yeong Cho
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0227012
Subject(s) - medicine , hypertrophic cardiomyopathy , incidence (geometry) , atrial fibrillation , dyslipidemia , population , chest pain , cohort , pediatrics , disease , environmental health , physics , optics
Temporal trends of the prevalence and incidence of hypertrophic cardiomyopathy (HCM) have not been well established in Asian populations. Using the Korean National Health Insurance Services database, we identified patients with a confirmed diagnosis of HCM between 2010 and 2016. The annual prevalence and incidence of HCM, and their clinical characteristics were investigated. The prevalence of HCM has increased from 0.016% (n = 6313) in 2010 to 0.031% (n = 13,035) in 2016. During a 7-year period, 13,229 patients were newly diagnosed with HCM. The incidence rate increased from 4.15 (per 100,000 person-years) in 2010 to 5.6 in 2016. The prevalence and incidence of HCM increased with age and peaked during the 70s, with male predominance in all age groups. Chest pain is the most frequent clinical presentation followed by shortness of breath and syncope. Hypertension and dyslipidemia were the two most common comorbidities. Heart failure and atrial fibrillation was diagnosed in about 1/3 and 1/4 of patients with HCM, respectively. The prevalence and incidence of HCM gradually increased from 2010 to 2016, possibly due to heightened recognition of the disease. Given the progressively high incidence of HCM with age and high prevalence of coexisting modifiable risk factors, continued efforts are required to increase awareness regarding HCM-related symptoms and potential complications.