Open AccessType 1 diabetes is associated with an increased risk of venous thromboembolism: A retrospective population-based cohort study
Author(s) -
YenChun Peng,
YuSheng Lin,
Chia-Hung Chen,
Kun-Yuan Tsai,
Yi-Chih Hung,
Hsuan-Ju Chen,
WeiChih Liao,
WenChao Ho
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0226997
Subject(s) - medicine , retrospective cohort study , type 1 diabetes , dyslipidemia , hazard ratio , proportional hazards model , diabetes mellitus , risk factor , cohort study , cohort , population , body mass index , obesity , endocrinology , confidence interval , environmental health
Background It has been unclear whether diabetes mellitus (DM) is positively associated with a risk of venous thromboembolism (VTE). In addition, whether the risk of VTE is altered in patients with type 1 diabetes (T1DM) has rarely been explored. Aim We investigated whether patients with T1DM are at a relatively high risk of VTE development. Methods We retrieved data from the National Health Insurance Research Database of Taiwan to conduct this retrospective cohort study. The T1DM group consisted of 4967 patients diagnosed as having T1DM before 2003. The non-T1DM group comprised 19 868 age- and sex-matched enrollees without T1DM. Cox proportional hazard regression analysis was used to investigate the hazard ratio of VTE in patients with T1DM relative to those without T1DM. Results During a mean follow-up period of 8.61 years, the risk of VTE in the T1DM group was 5.33-fold higher than in the non-T1DM group after adjusting for dyslipidemia, hypertension, stroke, lower leg fracture or surgery, and obesity. Further stratified analysis revealed that the risk of VTE was significantly high in both sexes and in all age groups below the age of 60. Conclusion T1DM appears to be an independent risk factor for VTE development.