Open AccessPersonalized therapy design for systemic lupus erythematosus based on the analysis of protein-protein interaction networks
Author(s) -
Elizabeth J. Brant,
Edward A. Rietman,
Giannoula Klement,
Marco Cavaglià,
Jack A. Tuszyński
Publication year - 2020
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0226883
Subject(s) - computational biology , systemic lupus erythematosus , protein–protein interaction , heat shock protein , ribosomal protein , proteome , lupus erythematosus , bioinformatics , biology , chemistry , medicine , immunology , microbiology and biotechnology , biochemistry , ribosome , rna , pathology , gene , antibody , disease
We analyzed protein expression data for Lupus patients, which have been obtained from publicly available databases. A combination of systems biology and statistical thermodynamics approaches was used to extract topological properties of the associated protein-protein interaction networks for each of the 291 patients whose samples were used to provide the molecular data. We have concluded that among the many proteins that appear to play critical roles in this pathology, most of them are either ribosomal proteins, ubiquitination pathway proteins or heat shock proteins. We propose some of the proteins identified in this study to be considered for drug targeting.