Open AccessOverweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM
Author(s) -
IWeng Yen,
ChienNan Lee,
Ming-Chia Lin,
Kang-Chih Fan,
Jung-Nan Wei,
KuanYu Chen,
SzuChi Chen,
Yi-Yun Tai,
ChunHeng Kuo,
Chia-Hung Lin,
ChihYao Hsu,
LeeMing Chuang,
Shuo Lin,
ChungYi Li
Publication year - 2019
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0225978
Subject(s) - overweight , gestational diabetes , medicine , obesity , body mass index , pregnancy , obstetrics , metabolic syndrome , insulin resistance , diabetes mellitus , odds ratio , risk factor , endocrinology , gestation , biology , genetics
Aim Overweight and obesity are important risk factors of gestational diabetes mellitus (GDM). Clustering of metabolic risk factors in early pregnancy may be a potential pathogenesis between the link of overweight/obesity and GDM. Since it remains unexplored, we investigated if overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM in this cohort study. Methods Total 527 women who visited National Taiwan University Hospital for prenatal care in between November 2013 to April 2018 were enrolled. Risk factors of GDM in the first prenatal visit (FPV) were recorded. Overweight/obesity was defined if body mass index ≥24 kg/m 2 . GDM was diagnosed from the result of a 75g oral glucose tolerance test in 24–28 gestational weeks. Results Overweight/obesity was associated with clustering of metabolic risk factors of GDM, including high fasting plasma glucose, high HbA1c, insulin resistance, high plasma triglyceride and elevated blood pressure in FPV ( p <0.05). There was a positive relationship between the number of metabolic risk factors and the incidence of GDM ( p <0.05). The odds ratios of HbA1c and diastolic blood pressure were higher in overweight/obese women, compared with those in normal-weight women. Conclusions Overweight/obesity is associated with clustering of metabolic risk factors in early pregnancy, which is correlated with higher risk of GDM. Our findings suggest that metabolic risk factors during early pregnancy should be evaluated in overweight/obese women.