Open AccessImported severe malaria and risk factors for intensive care: A single-centre retrospective analysis
Author(s) -
Alessandra D’Abramo,
Luciana Lepore,
Marco Iannetta,
Saba Gebremeskel Teklè,
Angela Corpolongo,
Laura Scorzolini,
Nazario Bevilacqua,
Andrea Mariano,
Maria Letizia Giancola,
Antonella Vulcano,
Micaela Maritti,
Alessandro Agresta,
Mario Antonini,
Umberto D’Alessandro,
Emanuele Nicastri
Publication year - 2019
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0225135
Subject(s) - malaria , multivariate analysis , medicine , intensive care unit , univariate analysis , retrospective cohort study , multivariate statistics , severity of illness , univariate , intensive care medicine , emergency medicine , immunology , statistics , mathematics
Objectives This study aims to identify the risk factors for intensive care (IC) in severe malaria patients admitted to the “Lazzaro Spallanzani” National Institute for Infectious Diseases, Rome, Italy. Methods All patients with confirmed severe malaria and hospitalized between 2007 and 2015 were included in the analysis and stratified into two groups: those requiring IC and those who did not. Five prognostic malaria scores were estimated; clinical severity at IC unit admission was assessed using the Sequential Organ Failure Assessment and the quick-Sequential Organ Failure Assessment scores. Univariate and multivariate analysis were performed to assess factors independently associated to IC. Results A total of 98 severe malaria patients were included; 10 of them required IC. There were no deaths or sequelae. Patients requiring IC had higher severity scores. At the multivariate analysis, only the number of World Health Organization criteria and the aspartate aminotransferase value were independently associated with the need of IC. Conclusions An early and accurate assessment of the severity score is essential for the management of severe malaria patients.